An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein

L Jelínková, H Jhun, A Eaton, N Petrovsky, F Zavala… - npj Vaccines, 2021 - nature.com
A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …

Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

KA Collins, R Snaith, MG Cottingham, SC Gilbert… - Scientific reports, 2017 - nature.com
The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …

Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile …

MD Porter, J Nicki, CD Pool, M DeBot… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria
vaccine candidate. There is an urgent need for models that can rapidly down-select novel …

Head-to-head comparison of soluble vs. Qβ VLP circumsporozoite protein vaccines reveals selective enhancement of NANP repeat responses

F Khan, M Porter, R Schwenk, M DeBot, P Saudan… - PloS one, 2015 - journals.plos.org
Circumsporozoite protein (CSP) of Plasmodium falciparum is a promising malaria vaccine
target. RTS, S, the most advanced malaria vaccine candidate consists of the central NANP …

A malaria vaccine candidate based on a hepatitis B virus core platform

M Sällberg, J Hughes, J Jones, TR Phillips, DR Milich - Intervirology, 2003 - karger.com
Objective: The recent success of a Plasmodium falciparum malaria vaccine consisting of
circumsporozoite (CS) protein (CSP) T and B cell epitopes has rekindled interest in the …

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

AM Mendes, M Machado, N Gonçalves-Rosa… - npj Vaccines, 2018 - nature.com
There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria
vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early …

Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in phase 1 first-in-human …

DAJ Friedman-Klabanoff, AA Berry, MA Travassos… - Vaccine, 2021 - Elsevier
Plasmodium falciparum circumsporozoite protein (CSP) is a major sporozoite surface
protein and a key target of pre-erythrocytic malaria subunit vaccines. A full-length …

A Full-Length Plasmodium falciparum Recombinant Circumsporozoite Protein Expressed by Pseudomonas fluorescens Platform as a Malaria Vaccine Candidate

AR Noe, D Espinosa, X Li, JGA Coelho-dos-Reis… - PloS one, 2014 - journals.plos.org
The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein,
which forms a dense coat on the sporozoite's surface. Preclinical research on CSP and …

The N-terminal domain of Plasmodium falciparum circumsporozoite protein represents a target of protective immunity

SE Bongfen, PM Ntsama, S Offner, T Smith, I Felger… - Vaccine, 2009 - Elsevier
The N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in
the search for a malaria vaccine in spite of being a target of inhibitory antibodies and …

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

L Foquet, CC Hermsen, GJ van Gemert… - The Journal of …, 2014 - Am Soc Clin Investig
Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that
resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 …