High‐mobility group box 1 (HMGB1), a nuclear protein, once released to the extracellular
space, facilitates pain signals as well as inflammation. Intraplantar or intraspinal application …

Background and Purpose High‐mobility group box 1 (HMGB 1), a nuclear protein, is actively
or passively released during inflammation. Recombinant human soluble thrombomodulin …

The number of patients with chronic pain continues to increase against the background of an
ageing society and a high incidence of various epidemics and disasters. One factor …

High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular
space under pathological conditions, plays a pronociceptive role in redox-dependent distinct …

Neuropathic pain, which is intolerable and persistent, arises as a direct consequence of a
lesion or disease affecting the somatosensory system and can be debilitating for the affected …

Although originally described as a highly conserved nuclear protein, high-mobility group box
1 protein (HMGB1) has emerged as a danger-associated molecular pattern molecule protein …

Background High-mobility group box-1 protein (HMGB1) is a nuclear protein that regulates
gene expression throughout the body. It can also become cytoplasmic and function as a …

Recent studies indicate that the release of high mobility group box 1 (HMGB1) following
nerve injury may play a central role in the pathogenesis of neuropathic pain. HMGB1 is …

Given that high mobility group box 1 (HMGB1), a nuclear protein, once released to the
extracellular space, promotes nociception, we asked if inactivation of HMGB1 prevents or …

Pro-inflammatory cytokine high mobility group box-1 (HMGB-1) is involved in inflammation in
the central nervous system, but less is known about its biological effects in the peripheral …