Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes
in bone biology, particularly to intramembranous ossification, not captured at other skeletal …

RUNX2 encodes the master bone transcription factor driving skeletal development in
vertebrates, and playing a specific role in craniofacial and skull morphogenesis. The …

Sagittal craniosynostosis is the most common form of craniosynostosis, affecting
approximately one in 5,000 newborns. We conducted, to our knowledge, the first genome …

One of the simplest models for examining the interplay between bone formation and
resorption is the junction between the cranial bones. Although only roughly a quarter of …

The skull vault is a complex, exquisitely patterned structure that plays a variety of key roles in
vertebrate life, ranging from the acquisition of food to the support of the sense organs for …

Craniosynostosis (CS) is a common congenital anomaly defined by premature fusion of one
or more cranial sutures. Syndromic CS involves additional organ anomalies or …

The cranial neural crest (CNC) undergoes complex molecular and morphological changes
during embryogenesis in order to form the vertebrate skull, and nearly three quarters of all …

Skeletal stem cells from the suture mesenchyme, which are referred to as suture stem cells
(SuSCs), exhibit long-term self-renewal, clonal expansion, and multipotency. These SuSCs …

Craniosynostosis, a developmental disorder resulting from premature closure of the gaps
(sutures) between skull bones, can be caused by excessive intramembranous ossification, a …

Our previous genome-wide association study (GWAS) for sagittal nonsyndromic
craniosynostosis (sNCS) provided important insights into the genetics of midline CS. In this …