Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
WY Sun, VA Tyurin, K Mikulska-Ruminska… - Nature chemical …, 2021 - nature.com
Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism
Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …
[HTML][HTML] PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and
chronic diseases and executed via oxygenation of polyunsaturated …
chronic diseases and executed via oxygenation of polyunsaturated …
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
WS Yang, KJ Kim, MM Gaschler… - Proceedings of the …, 2016 - National Acad Sciences
Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of …
SN Samovich, K Mikulska‐Ruminska… - Angewandte Chemie …, 2024 - Wiley Online Library
The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned
fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 …
fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 …
Oxidized PEs trigger death
Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS,
but the source and identity of lipid death signals that cause toxicity are poorly defined. New …
but the source and identity of lipid death signals that cause toxicity are poorly defined. New …
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione …
ferroptosis—a specialized death program triggered by insufficiency of glutathione …
Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE
TS Anthonymuthu, EM Kenny… - Journal of the …, 2018 - ACS Publications
sn2-15-Hydroperoxy-eicasotetraenoyl-phosphatidylethanolamines (sn 2-15-HpETE-PE)
generated by mammalian 15-lipoxygenase/phosphatidylethanolamine binding protein-1 (15 …
generated by mammalian 15-lipoxygenase/phosphatidylethanolamine binding protein-1 (15 …
[HTML][HTML] Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects …
TS Anthonymuthu, YY Tyurina, WY Sun… - Redox Biology, 2021 - Elsevier
Abstract Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a
ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX) …
ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX) …