The occurrence and progression of tumors can be established through a complex interplay
among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors …

Both lymph node metastases (LNMs) and tumour deposits (TDs) are included in colorectal
cancer (CRC) staging, although knowledge regarding their biological background is lacking …

Single cell RNA sequencing (scRNA-seq), a powerful tool for studying the tumor
microenvironment (TME), does not preserve/provide spatial information on tissue …

Abstract Epithelial‐mesenchymal transition (EMT), a biological process involving the
transformation of epithelial cells into mesenchymal cells, promotes tumour initiation and …

Background Tumor heterogeneity is contributed by tumor cells and the microenvironment.
Dynamics of tumor heterogeneity during colorectal cancer (CRC) progression have not been …

The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that
occurs during embryonic development and adult tissue homeostasis. This process involves …

Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …

Colorectal cancer (CRC) is one of the most devastating diseases that accounts for numerous
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …

Background The tumor-promoting role of tumor microenvironment (TME) in colorectal cancer
has been widely investigated in cancer biology. Cancer-associated fibroblasts (CAFs), as …

Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …