Background: Abdominal aortic calcification (AAC) is considered an independent predictor of
cardiovascular morbidity and mortality. Klotho, an anti-aging gene, has cardiovascular …

Background The mutation of the mouse klotho gene leads to a syndrome resembling aging
including calcification of the aorta. Objective To examine the relationship between serum …

Background and aims Abdominal aortic calcification (AAC) has been recognized as an
independent predictor of cardiovascular disease (CVD) incidence and mortality. The aim of …

Background: Klotho is a single transmembrane protein originally identified as an 'aging
suppressor'. Emerging evidence reveals that soluble Klotho (sKl) in the circulation plays …

Background Evidence suggests that the anti-aging protein a-Klotho is a central modulator of
mineral homeostasis. Circulating a-Klotho exerts endocrine activity and has been implicated …

Background Increased levels of serum Klotho have been associated with a reduced risk of
several cardiovascular diseases (CVD). However, limited studies exist on the association …

Background and aims Evidence indicates that serum Klotho concentration is associated with
mortality in patients with chronic kidney disease (CKD). However, evidence on this …

Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral
bone metabolism and might explain the relationship between chronic kidney disease (CKD) …

Background Klotho deficiency is a significant predictor of cardiovascular disease (CVD)-
related mortality and morbidity. However, research assessing the association between …

The Klotho gene, identified as an 'aging suppressor'gene, encodes a single-pass
transmembrane protein. The extracellular domain of Klotho is cleaved and released in the …