Background Ideally all participants in a randomised controlled trial (RCT) should fully
receive their allocated intervention; however, this rarely occurs in practice. Intervention …

Background Treatment adherence may influence the therapeutic effect that is observed in a
randomized controlled trial (RCT). Adherence may also be an indicator of research quality …

This review aimed to ascertain the extent to which nonadherence to treatment protocol is
reported and addressed in a cohort of published analyses of randomised controlled trials …

Aims This research aims to provide an overview of the consequences of undiagnosed
nonadherence (noninitiation, suboptimal implementation, nonpersistence) in randomized …

Pragmatic trials offer practical means of obtaining real‐world evidence to help improve
decision‐making in comparative effectiveness settings. Unfortunately, incomplete …

Background: The development and use of evidence based clinical practice guidelines is
widely advocated. Adherence with guidelines seems however to be moderate. To date no …

Background The registration of studies, especially in the case of clinical trials, is required by
the declaration of Helsinki and the policies of various scientific journals. However, numerous …

Objectives To review trial-based economic evaluations, identifying 1) the proportion
reporting adherence, 2) methods for assigning intervention costs according to adherence, 3) …

Background Understanding intervention fidelity is an essential part of the evaluation of
complex interventions because fidelity not only affects the validity of trial findings, but also …

Medication adherence in drug trials is suboptimal, affecting the quality of these studies and
adding significant costs. Nonadherence in this setting can lead to null findings, unduly large …