TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …
[HTML][HTML] Restoration of TET2 function blocks aberrant self-renewal and leukemia progression
Loss-of-function mutations in TET2 occur frequently in patients with clonal hematopoiesis,
myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML) and are associated …
myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML) and are associated …
[HTML][HTML] TET genes: new players in DNA demethylation and important determinants for stemness
Stem cells are defined as cells that have the ability to perpetuate themselves through self-
renewal and to generate functional mature cells by differentiation. During each stage …
renewal and to generate functional mature cells by differentiation. During each stage …
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition
S Bamezai, D Demir, AJ Pulikkottil, F Ciccarone… - Leukemia, 2021 - nature.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer
characterized by skewed epigenetic patterns, raising the possibility of therapeutically …
characterized by skewed epigenetic patterns, raising the possibility of therapeutically …
TET2: a cornerstone in normal and malignant hematopoiesis
H Kunimoto, H Nakajima - Cancer Science, 2021 - Wiley Online Library
Regulation of genome‐wide DNA methylation is fundamental for a variety of biological
processes such as mammalian development, stem cell function, cellular proliferation …
processes such as mammalian development, stem cell function, cellular proliferation …
TET2 loss dysregulates the behavior of bone marrow mesenchymal stromal cells and accelerates Tet2−/−-driven myeloid malignancy progression
R Li, Y Zhou, Z Cao, L Liu, J Wang, Z Chen, W Xing… - Stem cell reports, 2018 - cell.com
TET2 is a methylcytosine dioxygenase that regulates cytosine hydroxymethylation. Although
there are extensive data implicating a pivotal role of TET2 in hematopoietic stem/progenitor …
there are extensive data implicating a pivotal role of TET2 in hematopoietic stem/progenitor …
MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy) methylation and gene expression to maintain a neoplastic phenotype in T-ALL
CJ Poole, A Lodh, JH Choi, J Van Riggelen - Epigenetics & chromatin, 2019 - Springer
Background While aberrant DNA methylation is a characteristic feature of tumor cells, our
knowledge of how these DNA methylation patterns are established and maintained is …
knowledge of how these DNA methylation patterns are established and maintained is …
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
P Stolz, AS Mantero, A Tvardovskiy, E Ugur… - Nucleic Acids …, 2022 - academic.oup.com
Abstract DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
H Lopez-Bertoni, A Johnson, Y Rui, B Lal… - Signal transduction and …, 2022 - nature.com
DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET)
family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5 …
family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5 …
The TET2 interactors and their links to hematological malignancies
Ten‐eleven translocation (TET) family proteins are dioxygenases that oxidize 5‐
methylcytosine to 5‐hydroxymethylcytosine, 5‐formylcytosine, and 5‐carboxylcytosine in …
methylcytosine to 5‐hydroxymethylcytosine, 5‐formylcytosine, and 5‐carboxylcytosine in …