The subjective measures used to study mood disorders in humans cannot be replicated in
animals; however, the increasing application of objective neuropsychological methods …

Depression is one of the most common but poorly understood psychiatric conditions.
Although drug treatments and psychological therapies are effective in some patients, many …

Rationale Affective biases are hypothesised to contribute to the cause and treatment of
mood disorders. We have previously found that affective biases, associated with learning …

Rationale Affective states are known to influence behaviour in humans resulting in cognitive
affective biases, which may play an important role in the development and treatment of …

Major depressive disorder (MDD) affects more than 10% of the population, although our
understanding of the underlying aetiology of the disease and how antidepressant drugs act …

Major depressive disorder (MDD) is one of the leading global causes of disability. Symptoms
of MDD can vary person to person, and current treatments often fail to alleviate the poor …

Background Reliable measurement of affective state in animals is a significant goal of
animal welfare. Such measurements would also improve the validity of pre-clinical mental …

Background and Purpose Predicting the risk of drug‐induced adverse psychiatric effects is
important but currently not possible in non‐human species. We investigated whether the …

The biochemical targets for antidepressants are relatively well established, but we lack a
clear understanding of how actions at these proteins translate to clinical benefits. This study …

Cognitive abnormalities are a core feature of depression, and biases toward negatively
toned emotional information are common, but are they a cause or a consequence of …