Immune-cell activation and functional plasticity are closely linked to metabolic
reprogramming that is required to supply the energy and substrates for such dynamic …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Enhanced amino acid catabolism is a common response to inflammation, but the
immunologic significance of altered amino acid consumption remains unclear. The finding …

The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …

In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

Immunometabolism has emerged as a key focus for immunologists, with metabolic change
in immune cells becoming as important a determinant for specific immune effector …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Metabolites have functions in the immune system independent of their conventional roles as
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …

The concept that amino acids might function as ne~ rotrausmitters in the central nervous
system (CNS) arose largely during the 1960s through the pioneering studies of Curtis …