Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …

Abstract The transcription factor Keap1-Nrf2 system plays a key role in inflammation which is
involved in depression. We found lower expression of Keap1 and Nrf2 proteins in the …

Abstract Knowledge of the antioxidant defense in the stress-responding structures of the
CNS is of crucial importance, since oxidative damage is a phenomenon accompanying …

The transcription nuclear factor-erythroid factor 2-related factor 2 (Nrf2) plays a key role in
inflammation that is involved in depression. We previously reported that Nrf2 knock-out (KO) …

The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic
factor (BDNF) play a key role in depression. However, the molecular mechanisms …

A causative relationship between inflammation and depression is gradually gaining
consistency. Because Nrf2 participates in inflammation, we hypothesized that Nrf2 could …

Objective NOD-like receptor protein 1 (NLRP1) inflammasome complex has been recently
associated with chronic unpredictable mild stress (CUMS) model of depression. Our aim …

Abstract The discovery of Keap1–Nrf2 protein–protein interaction (PPI) inhibitors has
become a promising strategy to develop novel lead molecules against variety of stress …

Major depression disorder is a severe mental illness often linked with metabolic disorders.
Adiponectin is an adipocyte-secreted circulatory hormone with antidiabetic and glucose/lipid …

Background Abundant researches indicate that neuroinflammation has important roles in the
pathophysiology of depression. Our previous study found that the NLRP3 inflammasome …