Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

An understanding of underlying mechanisms involved in the activation of HIF‐1 in response
to both hypoxic stress and oncogenic signals has important implications for how these …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …

Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …

Hypoxia‐inducible factor 1 (HIF‐1) activates the transcription of genes involved in diverse
aspects of cellular and integrative physiology, including energy metabolism, cell growth …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …

Adaptation of cancer cells to their microenvironment is an important driving force in the
clonal selection that leads to invasive and metastatic disease. O 2 concentrations are …

Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …