Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study

B Conlon, B Langguth, C Hamilton, S Hughes… - Science Translational …, 2020 - science.org
Tinnitus is a phantom auditory perception coded in the brain that can be bothersome or
debilitating, affecting 10 to 15% of the population. Currently, there is no clinically …

Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans

KL Marks, DT Martel, C Wu, GJ Basura… - Science Translational …, 2018 - science.org
The dorsal cochlear nucleus is the first site of multisensory convergence in mammalian
auditory pathways. Principal output neurons, the fusiform cells, integrate auditory nerve …

Temporary suppression of tinnitus by modulated sounds

KM Reavis, VS Rothholtz, Q Tang, JA Carroll… - Journal of the …, 2012 - Springer
Despite high prevalence of tinnitus and its impact on quality life, there is no cure for tinnitus
at present. Here, we report an effective means to temporarily suppress tinnitus by amplitude …

Association of central noninvasive brain stimulation interventions with efficacy and safety in tinnitus management: a meta-analysis

JJ Chen, BS Zeng, CN Wu, B Stubbs… - … –Head & Neck …, 2020 - jamanetwork.com
Importance Tinnitus has a prevalence of 10% to 25% and is frequently associated with
numerous complications, such as neuropsychiatric disease. Traditional treatments have …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Noninvasive and invasive neuromodulation for the treatment of tinnitus: an overview

S Vanneste, D De Ridder - Neuromodulation: Technology at the Neural …, 2012 - Elsevier
Objective Nonpulsatile tinnitus is an auditory phantom percept characterized as a tone, or a
noise-like sound such as a hissing or buzzing sound or polyphonic, in the absence of any …

Head-to-head comparison of transcranial random noise stimulation, transcranial AC stimulation, and transcranial DC stimulation for tinnitus

S Vanneste, F Fregni, D De Ridder - Frontiers in psychiatry, 2013 - frontiersin.org
Tinnitus is the perception of a sound in the absence of an external sound stimulus. This
phantom sound has been related to plastic changes and hyperactivity in the auditory cortex …

Music-induced cortical plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment

C Pantev, H Okamoto, H Teismann - Frontiers in systems …, 2012 - frontiersin.org
Over the past 15 years, we have studied plasticity in the human auditory cortex by means of
magnetoencephalography (MEG). Two main topics nurtured our curiosity: the effects of …

Acoustic stimulation treatments against tinnitus could be most effective when tinnitus pitch is within the stimulated frequency range

R Schaette, O König, D Hornig, M Gross, R Kempter - Hearing research, 2010 - Elsevier
Acoustic stimulation with hearing aids or noise devices is frequently used in tinnitus therapy.
However, such behind-the-ear devices are limited in their high-frequency output with an …

Placebo-controlled vagus nerve stimulation paired with tones in a patient with refractory tinnitus: a case report

D De Ridder, M Kilgard, N Engineer… - Otology & …, 2015 - journals.lww.com
Objective Classical neuromodulation consists of applying electrical or magnetic stimuli to the
nervous system to modulate ongoing activity and connectivity. However, recently, an exciting …