Harnessing the Potential of Exosomal miRNAs: A Breakthrough in Rheumatoid Arthritis Diagnosis and Monitoring

J Gong, X Zhang, A Khan, J Liang, T Xiong, P Yang… - 2023 - researchsquare.com
Background Rheumatoid arthritis (RA) is an autoimmune disorder characterized by the
inflammation-induced joint damage. Timely diagnosis and treatment are crucial to prevent …

Identification of serum exosomal miRNA biomarkers for diagnosis of Rheumatoid arthritis

J Gong, X Zhang, A Khan, J Liang, T Xiong… - International …, 2024 - Elsevier
Background Rheumatoid arthritis (RA) is an autoimmune disorder characterized by
inflammation-induced joint damage, which can cause lasting disability. Therefore, early …

Deregulation of exosomal miRNAs in rheumatoid arthritis patients

MZ Hussain, MS Haris, M Rizwan, NS Ashraf… - Plos one, 2023 - journals.plos.org
Exosomes are small-diameter endosomal vesicles secreted in all biological fluids and play
biological/pathological roles in the cell. These pathological roles are played by exosome's …

Differential Expression Profiles of Plasma Exosomal microRNAs in Rheumatoid Arthritis

X Yang, Z Wang, M Zhang, Z Shuai - Journal of Inflammation …, 2023 - Taylor & Francis
Aim Differential expression maps of microRNAs (miRNAs) are connected to the autoimmune
diseases. This study sought to elucidate the expression maps of exosomal miRNA in plasma …

Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes

LF Wu, Q Zhang, XB Mo, J Lin, YL Wu, X Lu… - … & Molecular Medicine, 2022 - nature.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune
cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still …

Exosomal hsa-miR-335-5p and hsa-miR-483-5p are novel biomarkers for rheumatoid arthritis: A development and validation study

Y Yu, S Park, H Lee, EJ Kwon, HR Park, YH Kim… - International …, 2023 - Elsevier
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes
cartilage and bone damage. Exosomes are small extracellular vesicles that play a critical …

Exploration of exosomal miRNAs from serum and synovial fluid in arthritis patients

Y Xie, W Chen, M Zhao, Y Xu, H Yu, J Qin, H Li - Diagnostics, 2022 - mdpi.com
Arthritis is caused by inflammation, infection, degeneration, trauma, or other factors that
affect approximately 250 million people all over the world. Early diagnosis and prediction …

Exosome‐encapsulated miR‐6089 regulates inflammatory response via targeting TLR4

D Xu, M Song, C Chai, J Wang, C Jin… - Journal of cellular …, 2019 - Wiley Online Library
Exosome‐encapsulated microRNAs (miRNAs) have been identified as potential biomarkers
in autoimmune diseases. However, little is known about the role of exosome‐delivered …

MiR‐548a‐3p regulates inflammatory response via TLR4/NF‐κB signaling pathway in rheumatoid arthritis

Y Wang, F Zheng, G Gao, S Yan… - Journal of Cellular …, 2019 - Wiley Online Library
Currently published studies have implicated that microRNAs (miRNAs) including exosomes‐
encapsulated miRNAs play a critical role in rheumatoid arthritis (RA). Previously, we have …

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

R Kolhe, M Hunter, S Liu, RN Jadeja, C Pundkar… - Scientific reports, 2017 - nature.com
The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches
are limited to preventing progression of the disease. Recent studies have shown that …