Rupture of intracranial aneurysms causes subarachnoid hemorrhage (SAH), of which the
treatment remains the most difficult among cerebrovascular disorders even in this modern …

Acute brain injury is the leading cause of human death and disability worldwide, which
includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia …

Background: Ischemic stroke is the third leading cause of death and the most frequent cause
of permanent disability in adults worldwide. Tremendous advances have been made in …

A matricellular protein osteopontin (OPN) is considered to exert neuroprotective and healing
effects on neurovascular injuries in an acute phase of aneurysmal subarachnoid …

Experimental studies reported that osteopontin (OPN), a matricellular protein, is induced in
brain after subarachnoid hemorrhage (SAH). The aim of this study was to investigate the …

Osteopontin (OPN) is a pro-inflammatory cytokine that can be secreted from many cells
including activated macrophages and T-lymphocytes. Elevated levels of osteopontin in the …

Abstract Objective: Osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein, has
been reported to be protective against ischemic lesions, but effects of OPN on vascular …

Abstract Background: Subarachnoid hemorrhage (SAH)-induced early brain injury (EBI)
contributes to delayed ischemic neurological deficits, one of whose key pathologic …

Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and
mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently …

Osteopontin is a broadly expressed pleiotropic protein, and is attracting increased attention
because of its role in the pathophysiology of several inflammatory, degenerative …