Puberty is a time of considerable metabolic and hormonal change. Notably, puberty is
associated with a marked decrease in insulin sensitivity, on par with that seen during …

OBJECTIVE Insulin resistance (IR) is associated with diabetes. IR is higher during puberty in
both sexes, with some studies showing the increase to be independent of changes in …

Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with
prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth …

We studied the effect of pubertal development on insulin secretion. Intravenous glucose
tolerance tests were performed on 47 islet‐cell antibody negative siblings of diabetic …

Objective: Insulin resistance (IR) increases during puberty in normal children. IR is the first
adverse metabolic event of obesity, and the marker of the metabolic syndrome. We aimed to …

Previous cross-sectional studies show that puberty is associated with a reduction in insulin
sensitivity (SI), but no longitudinal studies have examined this change in detail. This study is …

Abstract Type 2 diabetes (T2DM), historically an adult disease, is now increasingly prevalent
in obese youth. Poor diet and increased sedentary behavior contribute to the increasing …

OBJECTIVE: To determine longitudinal changes in insulin sensitivity (SI), insulin secretion,
and β-cell function during puberty in white and black youth. STUDY DESIGN: The …

Puberty is commonly associated with an increase in insulin requirement in patients with
insulin-dependent diabetes. To investigate whether this pubertal increase in insulin …

Childhood obesity has become a major health concern in recent decades, especially with
regard to metabolic abnormalities that impart a high risk for future cardiovascular disease …