Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult
population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system …

The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit
the downstream transcriptional co-activators YAP and TAZ, which are implicated in various …

The Hippo tumor suppressor pathway is essential for development and tissue growth
control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2) …

The Hippo signaling pathway plays an essential role in adult tissue homeostasis and organ
size control. Abnormal regulation of Hippo signaling can be a cause for multiple types of …

Dysregulation of YAP localization and activity is associated with pathological conditions
such as cancer. Although activation of the Hippo phosphorylation cascade is known to …

The Hippo pathway plays important roles in controlling organ size and in suppressing
tumorigenesis through large tumor suppressor kinase 1/2 (LATS1/2)–mediated …

The Hippo tumor suppressor pathway regulates organ size and tissue homoeostasis in
response to diverse signaling inputs. The core of the pathway consists of a short kinase …

Abstract Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and
how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a …

The Hippo tumor suppressor pathway, originally defined in fruit flies, regulates cellular
proliferation and survival and exerts profound effects on normal mammalian cell fate and …

Hippo signaling controls the expression of genes regulating cell proliferation and survival
and organ size. The regulation of core components in the Hippo pathway by …