Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Chemotherapy is one of the widely used anticancer treatments that involves the use of
powerful cytotoxic drugs to stop tumor growth by targeting rapidly dividing cells through …

Despite frequent responses to chemotherapy, curative treatment remains elusive for the
majority of patients with metastatic solid tumors. By contrast, in testicular cancer, gestational …

The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by
exerting DNA damage. In essence, there are two major response phenotypes available to a …

Cytotoxic chemotherapy drugs damage proliferating cells primarily by interfering with mitosis
and we now know the molecular target of most of the drugs in clinical use. Even so, non …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Despite the progress in targeting particular molecular abnormalities specific to different
cancers (targeted therapy), chemo-and radiotherapies are still the most effective of all …

Chemotherapy is the only option for oncologists when a cancer has widely spread to
different body sites. However, almost all currently available chemotherapeutic drugs will …

The improvement in survival of childhood cancer observed across the past 50 years has
resulted in a growing acknowledgment that simply extending the lifespan of survivors is not …

Therapy-related cancers, defined as second primary cancers that arise as a consequence of
chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology …