We have developed a new technique for measurements of piconewton forces and
nanometer displacements in the millisecond time range caused by actin-myosin interaction …

The elementary events in energy transduction by the actomyosin motor, driven by ATP
hydrolysis, were directly recorded from multiple and single molecules using a recently …

To elucidate the mechanism of force generation by actomyosin motor, a measuring system
was constructed, in which an in vitro motility assay was combined with an optical trapping …

MUSCLE CONTRACTION and other biological motions are propelled by an actomyosin
motor driven by the chemical energy of ATP hydrolysis. Despite numerous studies, the …

Progress in imaging techniques and nano-manipulation of single molecules has been
remarkable. These techniques have allowed the accurate determination of myosin-head …

In order to explain the molecular mechanism of muscle contraction, it is crucial to know the
distribution of the sarcomere compliance of active muscle. Here, we directly measure the …

Recent progress in single–molecule detection techniques is remarkable. These techniques
have allowed the accurate determination of myosin–head–induced displacements and how …

The mechanical load borne by a molecular motor affects its force, sliding distance, and its
rate of energy transduction. The control of ATPase activity by the mechanical load on a …

We have developed a technique that allows mechanical and ligand-binding events in a
single myosin molecule to be monitored simultaneously. We describe how steps in the …

In order to determine the relative motions of an actin filament and a myosin molecule upon
hydrolysis of one ATP, an in vitro motility assay, in which individual actin filaments slide over …