Cleft palate, the most frequent congenital craniofacial birth defects in humans, arises from
genetic or environmental perturbations in the multi-step process of palate development …

Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct
from isolated cleft secondary palate (CP). Mutations in the Bmp target gene Msx1 in families …

Developmental abnormalities of craniofacial structures and teeth often occur sporadically
and the underlying genetic defects are not well understood, in part due to unknown gene …

The Msx1 homeobox gene is expressed at diverse sites of epithelial–mesenchymal
interaction during vertebrate embryogenesis, and has been implicated in signalling …

Cleft palate, including submucous cleft palate, is among the most common birth defects in
humans. While overt cleft palate results from defects in growth or fusion of the developing …

Cleft palate is a congenital disorder arising from a failure in the multistep process of palate
development. In its mildest form the cleft affects only the posterior soft palate. In more severe …

BMP signaling plays many important roles during organ development, including
palatogenesis. Loss of BMP signaling leads to cleft palate formation. During development …

Most vertebrate organs begin their initial formation by a common, developmentally
conserved pattern of inductive tissue interactions between two tissues. The developing tooth …

MSX1 has been considered a strong candidate for orofacial clefting, based on mouse
expression studies and knockout models, as well as association and linkage studies in …

Bmp4 is a downstream gene of Msx1 in early mouse tooth development. In this study, we
introduced the Msx1-Bmp4 transgenic allele to the Msx1 mutants in which tooth …