The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Apoptosis is a biological process that removes damaged, excess or infected cells through a
genetically controlled mechanism. This process plays a crucial role in organismal …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Mitochondria play an important role in the integration and transmission of cell death signals,
activating caspases and other cell death execution events by releasing apoptogenic …

The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

The Bcl-2 family of proteins is formed by pro-and antiapoptotic members. Together they
regulate the permeabilization of the mitochondrial outer membrane, a key step in apoptosis …

The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of
intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that …

Many different signals for cell death converge on outer mitochondrial membrane
permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and …

BCL‐2 family members are pivotal regulators of the apoptotic process. Mitochondria seem to
be a major site‐of‐action for these proteins. Several prominent alterations occur to …

Apoptosis is a form of programmed cell death critical for the development and homeostasis
of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the …