Activation of the dorsal columns is relayed to supraspinal centers, involved in pain
modulation, probably via the descending fibers in the dorsolateral funiculi (DLF). The …

Although spinal cord stimulation (SCS) of the dorsal columns is an established method for
treating chronic neuropathic pain, patients still suffer from a substantial level of pain. From a …

In addition to its involvement in the transmission of neuropathic pain, the dorsal column
system has been shown to have analgesic effects when electrically stimulated. The …

Spinal cord stimulation (SCS) may alleviate certain forms of neuropathic pain; its
mechanisms of action are, however, not fully understood. Previous studies have mainly …

The neurobiological mechanisms underlying the suppression of neuropathic pain by spinal
cord stimulation (SCS) are still incompletely known. The present study aims at exploring …

Rats with bilateral dorsal column (DC) lesions and chronic placement of stimulating
electrodes on DC nuclei (DCN) and sham-operated rats were studied using the tail …

As a sequel of complete spinal cord injury (SCI), patients often develop chronic pain which is
perceived at or just below the level of the lesion. Likewise, in animal models of SCI …

✓ Single neuronal units with physiological characteristics of superficial dorsal-horn neurons
were recorded extracellularly in laminae 1, 2, and 3 of cat spinal cord. When focal electrical …

The effect of dorsal column stimulation on spinothalamic tract cells was investigated in
anesthetized monkeys. The dorsal column stimuli were applied at midthoracic or at cervical …

The spinothalamic tract (STT) is a major ascending nociceptive pathway, interruption of
which by cordotomy is used for pain relief, whereas the dorsal column (DC) pathway is …