Dose optimization of piperacillin/tazobactam in critically ill children
PAJG De Cock, SC Van Dijkman… - Journal of …, 2017 - academic.oup.com
Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …
in critically ill infants and children, in order to develop an evidence-based dosing regimen …
Population pharmacokinetics of piperacillin/tazobactam in neonates and young infants
Z Li, Y Chen, Q Li, D Cao, W Shi, Y Cao, D Wu… - European journal of …, 2013 - Springer
Objectives To develop population pharmacokinetic (PK) models for piperacillin/tazobactam
in neonates and infants of less than 2 months of age in order to determine the appropriate …
in neonates and infants of less than 2 months of age in order to determine the appropriate …
Population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children
K Nichols, EK Chung, CA Knoderer… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …
Population pharmacokinetics and safety of piperacillin-tazobactam extended infusions in infants and children
C Thibault, J Lavigne, C Litalien, N Kassir… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Piperacillin-tazobactam (TZP) is frequently used to treat severe hospital-acquired infections
in children. We performed a single-center, pharmacokinetic (PK) trial of TZP in children …
in children. We performed a single-center, pharmacokinetic (PK) trial of TZP in children …
Single-dose pharmacokinetics of piperacillin and tazobactam in infants and children
MD Reed, J Goldfarb, TS Yamashita… - Antimicrobial agents …, 1994 - Am Soc Microbiol
The pharmacokinetics of piperacillin and tazobactam were assessed after single-dose
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …
Optimising piperacillin/tazobactam dosing in paediatrics
CW Tornøe, JJ Tworzyanski, MA Imoisili… - International journal of …, 2007 - Elsevier
Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …
Population pharmacokinetics of piperacillin/tazobactam in critically ill young children
JJ Cies, V Shankar, C Schlichting… - The Pediatric infectious …, 2014 - journals.lww.com
Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …
System-wide implementation of the use of an extended-infusion piperacillin/tazobactam dosing strategy: feasibility of utilization from a children's hospital perspective
KR Nichols, CA Knoderer, EG Cox, MB Kays - Clinical therapeutics, 2012 - Elsevier
BACKGROUND: Use of extended infusions of piperacillin/tazobactam (PT) in adult patients
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …
[HTML][HTML] Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in …
T Chongcharoenyanon, N Wacharachaisurapol… - International Journal of …, 2021 - Elsevier
Objectives To be effective, piperacillin/tazobactam (PTZ) unbound plasma levels need to be
above the minimum inhibitory concentration (MIC) at least 50% of the time between dosing …
above the minimum inhibitory concentration (MIC) at least 50% of the time between dosing …
Safety evaluation of piperacillin/tazobactam in very low birth weight infants
A Berger, V Kretzer, P Apfalter… - Journal of …, 2004 - Taylor & Francis
An open, non-comparative study was designed to evaluate the safety and toler-ance of
parenteral piperacillin/tazobactam in very low birth weight infants. Twenty-seven patients …
parenteral piperacillin/tazobactam in very low birth weight infants. Twenty-seven patients …
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