The tumour microenvironment plays a critical role in tumour progression and drug resistance
processes. Non-malignant cell players, such as fibroblasts, endothelial cells, immune cells …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …

The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Sažetak Tumors are three-dimensional (3D) entities characterized by complex structural
architecture which is necessary for adequate intercellular, intracellular and cell-to-matrix …

Tumours are surrounded by a host of noncancerous cells that fulfil both supportive and
suppressive roles within the tumour microenvironment (TME). The drive to understand the …

The complexity and diversity of the biochemical processes that occur during tumorigenesis
and metastasis are frequently over-simplified in the traditional in vitro cell cultures. Two …

Basic in vitro systems can be used to model and assess complex diseases, such as cancer.
Recent advances in this field include the incorporation of multiple cell types and …

In recent years, evidence has indicated that the tumor microenvironment (TME) plays a
significant role in tumor progression. Fibroblasts represent an abundant cell population in …