Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

S Nadkarni, J Smith… - Proceedings of the …, 2016 - National Acad Sciences
Although neutrophils are known to be fundamental in controlling innate immune responses,
their role in regulating adaptive immunity is just starting to be appreciated. We report that …

Neutrophils in pregnancy: New insights into innate and adaptive immune regulation

S Bert, EJ Ward, S Nadkarni - Immunology, 2021 - Wiley Online Library
The immunology of pregnancy has been the focus of many studies to better understand how
the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial …

Reduction in regulatory T cells in early pregnancy causes uterine artery dysfunction in mice

AS Care, SL Bourque, JS Morton, EP Hjartarson… - …, 2018 - Am Heart Assoc
Preeclampsia, fetal growth restriction, and miscarriage remain important causes of maternal
and perinatal morbidity and mortality. These complications are associated with reduced …

[HTML][HTML] Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua

D Croxatto, A Micheletti, E Montaldo, P Orecchia… - Mucosal …, 2016 - Elsevier
Innate lymphoid cells (ILCs) have a central role in innate defenses against pathogens,
lymphoid organogenesis, and tissue remodeling. They have been detected in human …

TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation

P Presicce, M Cappelletti… - Frontiers in …, 2020 - frontiersin.org
Accumulation of activated neutrophils at the feto-maternal interface is a defining hallmark of
intrauterine inflammation (IUI) that might trigger an excessive immune response during …

Identification of a novel neutrophil population: proangiogenic granulocytes in second-trimester human decidua

H Amsalem, M Kwan, A Hazan, J Zhang… - The Journal of …, 2014 - journals.aai.org
The maternal leukocytes of the first-trimester decidua play a fundamental role in implantation
and early development of the fetus and placenta, yet little is known regarding the second …

Unique roles of infiltrating myeloid cells in the murine uterus during early to midpregnancy

H Zhao, F Kalish, S Schulz, Y Yang… - The Journal of …, 2015 - journals.aai.org
Leukocyte infiltration into the uterus is a characteristic feature in early to midpregnancy, but
the composition and function of these leukocytes are not well understood. Using a pregnant …

Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity

DA López, AC Apostol, EJ Lebish, CH Valencia… - Cell reports, 2022 - cell.com
Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation and
infection, causing both acute and persistent changes to quiescence, mobilization, and …

Effector and activated T cells induce preterm labor and birth that is prevented by treatment with progesterone

M Arenas-Hernandez, R Romero, Y Xu… - The Journal of …, 2019 - journals.aai.org
Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …

Monocytes are progressively activated in the circulation of pregnant women

P Luppi, C Haluszczak, D Betters… - Journal of leukocyte …, 2002 - academic.oup.com
Pregnancy is characterized by the presence of generalized leukocyte activation. We used
flow cytometry to investigate changes in phenotype and intracellular cytokines of circulating …