Make and break the alarmone: regulation of (p) ppGpp synthetase/hydrolase enzymes in bacteria
S Ronneau, R Hallez - FEMS microbiology reviews, 2019 - academic.oup.com
Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and
to optimize their chances of survival in harsh conditions. One of the major stress responses …
to optimize their chances of survival in harsh conditions. One of the major stress responses …
Triggering the stringent response: signals responsible for activating (p) ppGpp synthesis in bacteria
SE Irving, RM Corrigan - Microbiology, 2018 - microbiologyresearch.org
The stringent response is a conserved bacterial stress response mechanism that allows
bacteria to respond to nutritional challenges. It is mediated by the alarmones pppGpp and …
bacteria to respond to nutritional challenges. It is mediated by the alarmones pppGpp and …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Two P or not two P: understanding regulation by the bacterial second messengers (p) ppGpp
G Bange, DE Brodersen, A Liuzzi… - Annual Review of …, 2021 - annualreviews.org
Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …
[HTML][HTML] (p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Identification of a broadly conserved family of enzymes that hydrolyze (p) ppApp
Bacteria produce a variety of nucleotide second messengers to adapt to their surroundings.
Although chemically similar, the nucleotides guanosine penta-and tetraphosphate [(p) …
Although chemically similar, the nucleotides guanosine penta-and tetraphosphate [(p) …
Regulatory themes and variations by the stress-signaling nucleotide alarmones (p) ppGpp in bacteria
Bacterial stress-signaling alarmones are important components of a protective network
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli
Y Zhang, E Zborníková, D Rejman, K Gerdes - MBio, 2018 - Am Soc Microbiol
The alarmone (p) ppGpp plays pivotal roles in basic bacterial stress responses by
increasing tolerance of various nutritional limitations and chemical insults, including …
increasing tolerance of various nutritional limitations and chemical insults, including …
Diversity in (p) ppGpp metabolism and effectors
Highlights•(p) ppGpp metabolic enzymes sense diverse stresses.•(p) ppGpp regulates
transcription initiation by targeting RNAP or GTP levels.•(p) ppGpp controls replication …
transcription initiation by targeting RNAP or GTP levels.•(p) ppGpp controls replication …