The P2 purinergic receptor family implicated in many physiological processes, including
neurotransmission, mechanical adaptation and inflammation, consists of ATP-gated non …

Extracellular ATP acts on the P2X family of ligand-gated ion channels and several members
of the P2Y family of G protein-coupled receptors to mediate intercellular communication …

Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in
many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization …

Abstract ATP (adenosine 5'-triphosphate) is one of the most important extracellular
regulatory molecules in the skeleton. Extracellular ATP and other nucleotides signal through …

We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic
receptors are involved in osteoblast mechanotransduction. In this study, our objective was to …

The concept that adenosine triphosphate (ATP) can act as an extracellular signaling
molecule via interactions with specific purinergic receptors to mediate a wide variety of …

Nucleotides, released in response to mechanical or inflammatory stimuli, signal through P2
nucleotide receptors in many cell types. Osteoclasts express P2X7 receptors (encoded by …

Osteocytes are considered the primary mechanosensors of bone, but the signaling
pathways they apply in mechanotransduction are still incompletely investigated and …

Osteocytes reside as a cellular network throughout the mineralised matrix of bone and are
considered the primary mechanosensors of this tissue. They sense mechanical stimulation …

ABSTRACT ATP release and subsequent activation of purinergic receptors has been
suggested to be one of the key transduction pathways activated by mechanical stimulation of …