With the rising prevalence of obesity and related health problems increases, there is
increased interest in the gastrointestinal system as a possible target for pharmacological or …

The gastrointestinal (GI) tract and specifically the most distal part of the small intestine, the
ileum, has become a renewed focus of interest for mechanisms targeting appetite …

Background: Activation of the ileal brake, by infusing lipid directly into the distal part of the
small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake …

Background The gastrointestinal tract elicits numerous signals regulating food intake and
satiety, and recently many studies have been performed to elucidate the mechanisms …

The" ileal brake" is the primary inhibitory feedback mechanism to control transit of a meal
through the gastrointestinal tract in order to optimize nutrient digestion and absorption …

Objective: The ileal brake is a feedback mechanism activated by nutrients, especially fat,
with marked effects on satiety. The effects of low doses of ileal fat on satiety are largely …

Peptidergic and neural signals arising from the presence of food in the gastrointestinal track
provide feedback signals to the brain about the nature and quantity of consumed nutrients …

Digestion and absorption of a meal are time-intensive processes. To optimize digestion and
absorption, transit of the meal through the gastrointestinal tract is regulated by a complex …

During a meal, multiple gastrointestinal sites are stimulated by ingested nutrients and their
digestion products, initiating local gastrointestinal actions and producing a variety of …

Previous studies have shown that ileal infusion of partially digested triglyceride inhibits
jejunal motility. The partial digest used in those studies contained a mixture of glycerol, free …