Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

T Farkhondeh, O Mehrpour, F Forouzanfar… - … Science and Pollution …, 2020 - Springer
Organophosphorus pesticides (OPs) are widely used for controlling pests worldwide. The
inhibitory effects of these pesticides on acetylcholinesterase lead to neurotoxic damages …

Cognitive impairment and neurodegenerative diseases development associated with organophosphate pesticides exposure: a review study

M Sarailoo, S Afshari, V Asghariazar… - Neurotoxicity …, 2022 - Springer
A significant body of literature emphasizes the role of insecticide, particularly
organophosphates (OPs), as the major environmental factor in the etiology of …

Lipid peroxidation, oxidative stress and acetylcholinesterase in rat brain exposed to organophosphate and pyrethroid insecticides

FM El-Demerdash - Food and chemical toxicology, 2011 - Elsevier
Oxidative stress by increased production of reactive oxygen species has been implicated in
the toxicity of many pesticides. Therefore, the aim of the present study was to investigate the …

Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells

MY Xu, P Wang, YJ Sun, L Yang, YJ Wu - Food and Chemical Toxicology, 2017 - Elsevier
Pesticides and heavy metals can be easily biomagnified in food chains and bioaccumulated
in individuals, thus pose significant threat to human health. However, their joint toxicity for …

Mitochondrial dysfunction and organophosphorus compounds

S Karami-Mohajeri, M Abdollahi - Toxicology and applied pharmacology, 2013 - Elsevier
Organophosphorous (OPs) pesticides are the most widely used pesticides in the agriculture
and home. However, many acute or chronic poisoning reports about OPs have been …

Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos

JE Lee, JH Park, IC Shin, HC Koh - Toxicology and applied pharmacology, 2012 - Elsevier
Reactive oxidative species (ROS) generated by environmental toxicants including pesticides
could be one of the factors underlying the neuronal cell damage in neurodegenerative …

Effects of commonly used pesticides in China on the mitochondria and ubiquitin-proteasome system in Parkinson's disease

T Chen, J Tan, Z Wan, Y Zou… - International journal of …, 2017 - mdpi.com
Evidence continues to accumulate that pesticides are the leading candidates of
environmental toxins that may contribute to the pathogenesis of Parkinson's disease. The …

Effect of pesticides on cell survival in liver and brain rat tissues

M Astiz, MJT De Alaniz, CA Marra - Ecotoxicology and environmental …, 2009 - Elsevier
Pesticides are the main environmental factor associated with the etiology of human
neurodegenerative disorders such as Parkinson's disease. Our laboratory has previously …

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues–Chlorpyrifos and Carbofuran via oxidative stress

DJ Fu, P Li, J Song, SY Zhang, HZ Xie - Toxicology In Vitro, 2019 - Elsevier
Multi-component pesticide residues, especially pesticide residues with synergistic toxicity,
are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) …

Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain

WY Wani, S Gudup, A Sunkaria, A Bal, PP Singh… - …, 2011 - Elsevier
Dichlorvos is a synthetic insecticide that belongs to the family of chemically related
organophosphate (OP) pesticides. It can be released into the environment as a major …