[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …
'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects
HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …
Ru(CO)3Cl(Glycinate) (CORM-3): A Carbon Monoxide–Releasing Molecule with Broad-Spectrum Antimicrobial and Photosensitive Activities Against Respiration and Cation …
JL Wilson, HE Jesse, B Hughes, V Lund… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: Carbon monoxide (CO) delivered to cells and tissues by CO-releasing molecules (CO-
RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru (CO) …
RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru (CO) …
Analysis of the Bacterial Response to Ru(CO)3Cl(Glycinate) (CORM-3) and the Inactivated Compound Identifies the Role Played by the Ruthenium Compound and …
S McLean, R Begg, HE Jesse, BE Mann… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Aims: Carbon monoxide (CO)-releasing molecules (CO-RMs) are being developed
with the ultimate goal of safely utilizing the therapeutic potential of CO clinically. One such …
with the ultimate goal of safely utilizing the therapeutic potential of CO clinically. One such …
The carbon monoxide‐releasing molecule, corm‐3 (ru(co)3cl(glycinate)), targets respiration and oxidases in campylobacter jejuni, generating hydrogen peroxide
H Smith, BE Mann, R Motterlini, RK Poole - IUBMB life, 2011 - Wiley Online Library
Carbon monoxide (CO) is a classical respiratory inhibitor, but CO‐releasing molecules (CO‐
RMs) have therapeutic value, increasing phagocytosis, and reducing sepsis‐induced …
RMs) have therapeutic value, increasing phagocytosis, and reducing sepsis‐induced …
Examining the antimicrobial activity and toxicity to animal cells of different types of CO-releasing molecules
LS Nobre, H Jeremias, CC Romão, LM Saraiva - Dalton Transactions, 2016 - pubs.rsc.org
Transition metal carbonyl complexes used as CO-releasing molecules (CORMs) for
biological and therapeutic applications may exhibit interesting antimicrobial activity …
biological and therapeutic applications may exhibit interesting antimicrobial activity …
Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators
KS Davidge, G Sanguinetti, CH Yee, AG Cox… - Journal of Biological …, 2009 - ASBMB
Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-
inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value …
inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value …
Differential Antibacterial Activity Against Pseudomonas aeruginosa by Carbon Monoxide-Releasing Molecules
M Desmard, R Foresti, D Morin… - Antioxidants & redox …, 2012 - liebertpub.com
Aims: Carbon monoxide (CO) delivered in a controlled manner to cells and organisms
mediates a variety of pharmacological effects to the extent that CO-releasing molecules (CO …
mediates a variety of pharmacological effects to the extent that CO-releasing molecules (CO …
CO-releasing metal carbonyl compounds as antimicrobial agents in the post-antibiotic era
LK Wareham, RK Poole, M Tinajero-Trejo - Journal of Biological Chemistry, 2015 - ASBMB
The possibility of a" post-antibiotic era" in the 21st century, in which common infections may
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …
Ruthenium (II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties
Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate
immune system, and have anti-inflammatory and antibacterial properties. While the first …
immune system, and have anti-inflammatory and antibacterial properties. While the first …