Background: Because of the rapid spread of antimicrobial resistance and the slow
development of novel antimicrobials, Gram-negative infections treatments are challenging …

Background The use of combined antibiotic therapy has become an option for infections
caused by multidrug-resistant (MDR) bacteria. The time-kill (TK) assay is considered the …

Background: In view of the paucity of clinical evidence, in vitro studies are needed to find
antibiotic combinations effective against multidrug-resistant Gram-negative bacteria …

Testing for antimicrobial interactions has gained popularity in the last decade due to the
increasing prevalence of drug-resistant organisms and limited options for the treatment of …

Abstract Background and Aims Emergence of multidrug resistance in non‐fermenting Gram‐
negative bacilli is a threat to public health. Combination therapy is a strategy for the …

The lack of treatment for multidrug-resistant (MDR) Enterobacteriaceae often leads to the
use of double or triple antibiotic combinations to increase the option of clinical success. This …

Context The emergence of drug resistant pathogens pose major threat to hospitalized
patients as well as to the community associated with increased mortality and morbidity. The …

Despite the marketing of a series of new antibiotics for antibiotic-resistant gram-positive
bacteria, no new agents for multiple-antibiotic-resistant gram-negative infections will be …

The aim of the study was to assess the microbiological activity and clinical efficacy of colistin
and rifampin combination against multidrug-resistant (MDR) Pseudomonas aeruginosa …

Background: Multidrug resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii
and Stenotrophomonas maltophilia have a leading role in nosocomial infections, including …