Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create
multiple genetic changes in a single event. Activity of A3s results in striking 'mutation …

The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

The somatic mutations in a cancer genome are the aggregate outcome of one or more
mutational processes operative through the lifetime of the individual with cancer,,. Each …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

INTRODUCTION Extensive tumor sequencing efforts have transformed the way in which
cancer driver genes are identified. Appropriate statistical modeling is crucial for …

Thousands of somatic mutations accrue in most human cancers, and their causes are
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …

Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …