Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a
significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD …

Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-
dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of
frontotemporal dementia. Most pathogenic GRN mutations result in progranulin …

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene
causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a …

Homozygous mutations of granulin precursor (GRN) lead to neuronal ceroid lipofuscinosis,
a severe neurodevelopmental disease, in humans and neuroinflammation in mice …

Frontotemporal dementia (FTD) is a common neurogenerative disorder characterized by
progressive degeneration in the frontal and temporal lobes. Heterozygous mutations in the …

Progranulin (PGRN) haploinsufficiency resulting from loss-of-function mutations in the
PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 …

Background Mutations in the progranulin (PGRN) encoding gene, GRN, cause familial
frontotemporal dementia (FTD) and neuronal ceroid lipofuscinosis and is also implicated in …

Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders
characterized by cognitive and behavioral impairments. Heterozygous mutations in …