Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis
WE Copeland, L Shanahan… - Journal of Child …, 2022 - Wiley Online Library
Background Longitudinal studies are needed to clarify whether early adversities are
associated with advanced methylation age or if they actually accelerate methylation aging …
associated with advanced methylation age or if they actually accelerate methylation aging …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model
We expand upon prior work (Gibbons et al., 2012) relating childhood stressor effects,
particularly harsh childhood environments, to risky behavior and ultimately physical health …
particularly harsh childhood environments, to risky behavior and ultimately physical health …
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)
Research examining the association between exposure to a wide range of adverse
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of …
Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …
is associated with altered DNA methylation signatures, which might be more common in …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
[HTML][HTML] Dimensions of childhood adversity differentially affect biological aging in major depression
Adverse childhood experiences have been consistently linked with physical and mental
health disorders in adulthood that may be mediated, in part, via the effects of such …
health disorders in adulthood that may be mediated, in part, via the effects of such …
[HTML][HTML] Childhood adversity and DNA methylation in two population-based cohorts
Childhood adversity affects later health, but the underlying molecular mechanisms are
unclear. Although there is some evidence from animal models and case-control studies of a …
unclear. Although there is some evidence from animal models and case-control studies of a …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
[HTML][HTML] Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study
Background Epigenetic mechanisms may partly explain the persistent effects of adverse
childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict …
childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict …