Inflammatory bowel diseases (IBDs) are increasingly common diseases characterized by
chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial …

Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin, which
has shown various pharmacological activities including anti-inflammatory, antitumor …

Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds
of immunological diseases including colitis. However, there are few drugs targeting …

Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal
role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome …

Objectives Wedelolactone exhibits regulatory effects on some inflammatory diseases.
However, the anti‐inflammatory mechanism of wedelolactone has not been entirely …

Chronic ulceration of the colon is associated with the activation of TLR4/NF-κB and
P2X7R/NLRP3 signaling pathways. We investigated the effect of individual or combined …

Context Ulcerative colitis (UC) is a common acute or chronic intestinal disease with an
imbalance of inflammation. Picroside II (P-II) exerts a protective role in various inflammation …

Background: Ononin, a flavonoid isolated from Astragalus membranaceus root, is the active
ingredient of A. membranaceus and has potential anti‐inflammatory properties, but its effect …

Although the etiology of inflammatory bowel disease is still uncertain, increasing evidence
indicates that the excessive activation of NLRP3 inflammasome plays a major role …

Inhibition of the activation of the NLR family pyrin domain‑containing 3 (NLRP3)
inflammasome has previously been reported to confer protection against post‑infectious …