For at least hundreds of thousands of years, humans lived as hunters–gatherers in small
tribal bands. Over the past few thousands of years, technological and societal changes have …

It is 150 years since Darwin published On the Origin of Species, but his insights and the
others that followed are underused in the study of pain. An understanding of evolutionary …

Our understanding of the biology of pain is limited by our ignorance about its evolution. We
know little about how states in other species showing various degrees of apparent similarity …

Pain has an inherent capacity to instigate negative emotion (notably fear), grasp the
attention of the pain sufferer, and motivate actions to reduce, avoid, or escape the painful …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

There are many known risk factors for chronic pain conditions, yet the biological
underpinnings that link these factors to abnormal processing of painful signals are only just …

Dr. Marchand's article “Mechanisms Challenges of the Pain Phenomenon”(https://www.
frontiersin. org/articles/10.3389/fpain. 2020.574370/full) provides a summary of the evolution …

A great deal of mechanistic work conducted in pain research is concerned with answering
the question of why a certain stimulus should be perceived as painful or how the nervous …

Evolutionary models of chronic pain are relatively undeveloped, but mainly concern
dysregulation of an efficient acute defence, or false alarm. Here, a third possibility, mismatch …

Enormous progress in understanding the mechanisms that mediate pain can be augmented
by an evolutionary medicine perspective on how the capacity for pain gives selective …