Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …

Background Albuterol is the drug most widely used as asthma treatment among African
Americans despite having a lower bronchodilator drug response (BDR) than other …

Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Background The epigenetic mechanisms of asthma remain largely understudied in African
Americans and Hispanics/Latinos, two populations disproportionately affected by asthma …

Background Asthma is a chronic respiratory disease which is not curable, yet some patients
experience spontaneous remission. We hypothesized that epigenetic mechanisms may be …

Background Asthma is highly heterogeneous, and severity evaluation is key to asthma
management. DNA methylation (DNAm) contributes to asthma pathogenesis. This study …

Background Nasal (airway) epithelial methylation profiles have been associated with
asthma, but the effects of such profiles on expression of distant cis-genes are largely …

Background Asthma is a common respiratory disease that is characterized by bronchial
hyperresponsiveness and airway obstruction due to chronic airway inflammation. Atopic …

Current smoking contributes to worsened asthma prognosis and more severe symptoms and
limits the beneficial effects of corticosteroids. As the nasal epithelium can reflect smoking …

Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …