Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
HS Budi, S Izadi, A Timoshin, SH Asl, B Beyzai… - … , Biology and Medicine, 2021 - Elsevier
HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of
cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore …
cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore …
Inhibition of HIF-1α/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells
V Karpisheh, JF Afjadi, MN Afjadi, MS Haeri… - International Journal of …, 2021 - Elsevier
Increased expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor
microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer …
microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer …
Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N, N, N-trimethyl chitosan nanoparticles potently reduces cancer cell progression
The immunosuppressive nature of the tumor microenvironment is a critical problem that
should be considered before the design of immunotherapies. Interleukin (IL)-6 and its …
should be considered before the design of immunotherapies. Interleukin (IL)-6 and its …
Silencing of HIF-1α/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression
F Hajizadeh, SM Ardebili, MB Moornani… - European journal of …, 2020 - Elsevier
Abstract Induction of Hypoxia Inducible Factor (HIF) as a direct consequence of oxygen
deficiency in tumor tissues is a potent stimulus of CD73 (ecto-5′-nucleotidase) expression …
deficiency in tumor tissues is a potent stimulus of CD73 (ecto-5′-nucleotidase) expression …
Superparamagnetic iron oxide nanoparticles modified with polyethylenimine and galactose for siRNA targeted delivery in hepatocellular carcinoma therapy
Z Yang, J Duan, J Wang, Q Liu, R Shang… - International journal …, 2018 - Taylor & Francis
Introduction A safe and effective in vivo siRNA delivery system is a prerequisite for liver
tumor treatment based on siRNA cancer therapeutics. Nanoparticles based on …
tumor treatment based on siRNA cancer therapeutics. Nanoparticles based on …
Simultaneous blockade of TIGIT and HIF-1α induces synergistic anti-tumor effect and decreases the growth and development of cancer cells
M Fathi, S Bahmanpour, A Barshidi, H Rasouli… - International …, 2021 - Elsevier
Purpose T-cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint that is
overexpressed on both immune cells and some cancer cells. TIGIT can alter the anti-tumor …
overexpressed on both immune cells and some cancer cells. TIGIT can alter the anti-tumor …
Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells
J Chen, Y Dou, Y Tang, X Zhang - Nanomedicine: Nanotechnology, Biology …, 2020 - Elsevier
We developed a STAT3 silencing siRNA to both tumor cells and M2 macrophages. The dual-
targeting system prepared by electronic self-assembly was composed of folic acid …
targeting system prepared by electronic self-assembly was composed of folic acid …
Trimethyl-chitosan coated gold nanoparticles enhance delivery, cellular uptake and gene silencing effect of EGFR-siRNA in breast cancer cells
L Baghani, N Noroozi Heris, F Khonsari… - Frontiers in Molecular …, 2022 - frontiersin.org
Purpose: Despite the promising therapeutic effects of gene silencing with small interfering
RNAs (siRNAs), the challenges associated with delivery of siRNAs to the tumor cells in vivo …
RNAs (siRNAs), the challenges associated with delivery of siRNAs to the tumor cells in vivo …
Simultaneous silencing of the A2aR and PD-1 immune checkpoints by siRNA-loaded nanoparticles enhances the immunotherapeutic potential of dendritic cell …
FK Kiani, S Izadi, EA Dezfouli, F Ebrahimi… - Life sciences, 2022 - Elsevier
Following various immunotherapies, lack of proper anti-tumor immune responses is
considered a significant problem in novel cancer therapeutic approaches. The expression of …
considered a significant problem in novel cancer therapeutic approaches. The expression of …
Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
S Bastaki, S Aravindhan, NA Saheb, MA Kashani… - Life Sciences, 2021 - Elsevier
Immunotherapy methods using potential tumor microenvironment modulators have elicited
durable therapeutic responses in cancer treatment. Immune checkpoint molecule …
durable therapeutic responses in cancer treatment. Immune checkpoint molecule …
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