Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange

BE Kidd, ME Gemeinhardt, JA Mashni, JL Gesiorski… - Molecules, 2023 - mdpi.com
The present work investigates the potential for enhancing the NMR signals of DNA
nucleobases by parahydrogen-based hyperpolarization. Signal amplification by reversible …

Transfer of SABRE-derived hyperpolarization to spin-1/2 heteronuclei

AN Pravdivtsev, AV Yurkovskaya, H Zimmermann… - Rsc Advances, 2015 - pubs.rsc.org
In this paper, we describe a method of hyper-polarizing “insensitive” Nuclear Magnetic
Resonance (NMR) nuclei by exploiting the SABRE (Signal Amplification By Reversible …

Generalizing, extending, and maximizing nitrogen-15 hyperpolarization induced by parahydrogen in reversible exchange

JFP Colell, AWJ Logan, Z Zhou… - The Journal of …, 2017 - ACS Publications
Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR
hyperpolarization method that uses cheap and readily available para-hydrogen as a …

Nuclear Spin Hyperpolarization of NH2‐ and CH3‐Substituted Pyridine and Pyrimidine Moieties by SABRE

R Mandal, P Pham, C Hilty - ChemPhysChem, 2020 - Wiley Online Library
Hyperpolarization of N‐heterocycles with signal amplification by reversible exchange
(SABRE) induces NMR sensitivity gains for biological molecules. Substitutions with …

Direct hyperpolarization of nitrogen-15 in aqueous media with parahydrogen in reversible exchange

JFP Colell, M Emondts, AWJ Logan… - Journal of the …, 2017 - ACS Publications
Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even
continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization …

Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization

T Theis, ML Truong, AM Coffey… - Journal of the …, 2015 - ACS Publications
Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to
nitrogen-15 in pyridine and nicotinamide (vitamin B3 amide) by conducting “signal …

15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH

ML Truong, T Theis, AM Coffey… - The journal of …, 2015 - ACS Publications
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization
technique that enables nuclear spin polarization enhancement of molecules via concurrent …

Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

KV Kovtunov, LM Kovtunova… - Angewandte …, 2017 - Wiley Online Library
The hyperpolarization of heteronuclei via signal amplification by reversible exchange
(SABRE) was investigated under conditions of heterogeneous catalysis and microtesla …

Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)

KX Moreno, K Nasr, M Milne, AD Sherry… - Journal of Magnetic …, 2015 - Elsevier
Here we report the polarization of the solvent OH protons by SABRE using standard iridium-
based catalysts under slightly acidic conditions. Solvent polarization was observed in the …

Frequency‐Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly‐Coupled Spin Systems

AN Pravdivtsev, JB Hövener, AB Schmidt - ChemPhysChem, 2022 - Wiley Online Library
We present a selectively pulsed (SP) generation of sequences to transfer the spin order of
parahydrogen (pH2) to heteronuclei in weakly coupled spin systems. We analyze and …