Oxygen is both an environmental and developmental signal that governs important cellular
pathways. Therefore, hypoxia (or low oxygen tensions) is part of both physiological and …

Hypoxia induces profound changes in the cellular gene expression profile. The discovery of
a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and …

A sufficient supply molecular oxygen is essential for the maintenance of physiologic
metabolism and bioenergetic homeostasis for most metazoans. For this reason …

Cellular responses to low oxygen (hypoxia) are fundamental to normal physiology and to the
pathology of many common diseases. Hypoxia-inducible factor (HIF) is central to this by …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

The adaptive responses to hypoxia include the transcriptional activation of various genes
like those encoding for glycolytic enzymes, growth factors and vasoactive peptides that tend …

All organisms respond to changes in their environment by activating complex signaling
cascades. The “hypoxia-signaling cascade” is activated in response to low oxygen …

Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate
specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription …

Mammalian cells constantly encounter hypoxia, which is a stress condition occurring during
development and physiological processes. To adapt to this inevitable condition, cells …

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular
transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene …