Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

The nuclear factor (NF)-κB is considered the master regulator of inflammatory responses.
Studies in mouse models have established this transcription factor as an important mediator …

Nuclear factor-κB (NF-κB) is one of the most important transcription factors; it has a key role
in inflammatory and immune responses, cell adhesion, developmental signals, and anti …

Although airway epithelial cells provide important barrier and host defense functions, a
crucial role for these cells in development of acute lung inflammation and injury has not …

At present, therapeutic interventions to treat acute lung injury (ALI) or acute respiratory
distress syndrome (ARDS) remain largely limited to lung-protective strategies, as no real …

Although the role of NF-κB in the pathogenesis of sepsis and septic shock has been
extensively studied, little is known about the causative contribution of endothelial-intrinsic …

We investigated the impact of inflammatory signaling in airway epithelial cells on host
defense against Pseudomonas aeruginosa, a major cause of nosocomial pneumonia. In …

Tumor necrosis factor-α (TNFα) has emerged as a pivotal effector critically correlated with
disease severity in acute lung injury (ALI). Because both the excessive activation of …

Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure
that has a rapid onset, a high mortality rate, and for which there is no effective …

Acute lung injury (ALI) remains a serious health issue with little improvement in our
understanding of the pathophysiology and therapeutic approaches. We investigated the …