Breast cancer is the most common cancer among women, accounting for about 30% of all
cancers. In contrast, breast cancer is a rare disease in men, accounting for less than 1% of …

The worldwide incidence of breast cancer affects 1.2 million women each year. In contrast to
the high occurrence of this malady, a decline in mortality is reported among industrialized …

Somatic changes in the genome of breast cancer cells include amplifications, deletions and
gene mutations. Several chromosome regions harboring known oncogenes are found …

Since the initial discovery that pathogenic germline alterations in BRCA 1/2 increase
susceptibility to breast and ovarian cancer, many additional genes have now been …

A role for BRCA1 and BRCA2 in the control of genome integrity easily fits a tumor
suppressor model. It is well established that mutations in DNA repair genes lead to genomic …

More has been written about the epidemiology of breast cancer than possibly any other form
of cancer affecting mankind. However, in the face of this intense interest, only a paucity of …

The risk of developing breast cancer is multifactorial and, at times, modifiable. However, the
risk imposed by family history and hereditary pathogenic variants in a person's genetic code …

The etiology of breast cancer involves a complex interplay of various factors, including
genetic alterations. Many studies have been devoted to the identification and …

Publisher Summary This chapter highlights the genetic studies concerned with human
breast cancer and discusses the background of breast cancer histology and clinical aspects …

Breast cancer is the second most common cancer among women and the second leading
cause of cancer death in the US. In 2006, more than 214,000 new breast cancer cases were …