Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …

More effective use of targeted anti-cancer drugs depends on elucidating the connection
between the molecular states induced by drug treatment and the cellular phenotypes …

Targeted cancer therapies have produced substantial clinical responses, but most tumors
develop resistance to these drugs. Here, we describe a pharmacogenomic platform that …

The systematic translation of cancer genomic data into knowledge of tumour biology and
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …

The determination of individual cell trajectories through a high-dimensional cell-state space
is an outstanding challenge for understanding biological changes ranging from cellular …

An increasingly recognized component of resistance to tyrosine kinase inhibitors (TKI)
involves persistence of a drug-tolerant subpopulation of cancer cells that survive despite …

In recent experiments on isogenetic cancer cell lines, it was observed that exposure to high
doses of anticancer drugs can induce the emergence of a subpopulation of weakly …

Accumulating evidence implicates heterogeneity within cancer cell populations in the
response to stressful exposures, including drug treatments. While modeling the acute …

Background Tumor resistance to chemotherapy may be present at the beginning of
treatment, develop during treatment, or become apparent on re-treatment of the patient. The …

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant
cells under conditions that are lethal to the majority of the population. Stress tolerance is …