Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is
no method for its routine assessment in human tumours. Gene signatures are currently …

Purpose: There is increasing interest in radiogenomics and the characterization of molecular
profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was …

Late adverse tissue reactions affect up to a fifth of cancer patients receiving radiotherapy,
with several clinical parameters known to influence normal tissue responses. Despite careful …

PURPOSE: Development of a radiosensitivity predictive assay is a central goal of radiation
oncology. We reasoned a gene expression model could be developed to predict intrinsic …

Background Radiation therapy is among the most effective and commonly used therapeutic
modalities of cancer treatments in current clinical practice. The fundamental paradigm that …

The 60 cell lines of the National Cancer Institute Anticancer Drug Screen (NCI-60) constitute
the most extensively characterized in vitro cancer cell model. They have been tested for …

Purpose: To review the many changes which have occurred in the past decades in the field
of predicting outcome after radiotherapy from biological characteristics of the tumour or …

New insights into molecular mechanisms responsible for cellular radiation response are
coming from recent basic radiobiological studies. Preliminary data supporting the concept of …

BACKGROUND AND PURPOSE: The genetic profile as determined by microarray is
considered to be an ideal marker of the individual radiosensitivity. However, it is still an open …

Ionizing radiation (IR) is an ever-present hazard to humans primarily due to its mutagenic,
carcinogenic, and cell killing ability. In addition to causing DNA damage, irradiation initiates …