Origins and evolution of a transmissible cancer

CA Rebbeck, R Thomas, M Breen, AM Leroi, A Burt - Evolution, 2009 - academic.oup.com
Canine transmissible venereal tumor (CTVT) is an infectious disease of dogs. Remarkably,
the infectious agent is the cancerous cell itself. To investigate its origin and spread, we …

[HTML][HTML] Clonal origin and evolution of a transmissible cancer

C Murgia, JK Pritchard, SY Kim, A Fassati, RA Weiss - Cell, 2006 - cell.com
The transmissible agent causing canine transmissible venereal tumor (CTVT) is thought to
be the tumor cell itself. To test this hypothesis, we analyzed genetic markers including major …

Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage

EP Murchison, DC Wedge, LB Alexandrov, B Fu… - Science, 2014 - science.org
Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a
transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two …

The cancer which survived: insights from the genome of an 11 000 year-old cancer

A Strakova, EP Murchison - Current opinion in genetics & development, 2015 - Elsevier
The canine transmissible venereal tumour (CTVT) is a transmissible cancer that is spread
between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT affects …

Somatic evolution and global expansion of an ancient transmissible cancer lineage

A Baez-Ortega, K Gori, A Strakova, JL Allen, KM Allum… - Science, 2019 - science.org
INTRODUCTION The canine transmissible venereal tumor (CTVT) is a sexually transmitted
cancer that manifests as genital tumors in dogs. This cancer first arose in an individual …

The changing global distribution and prevalence of canine transmissible venereal tumour

A Strakova, EP Murchison - BMC veterinary research, 2014 - Springer
Background The canine transmissible venereal tumour (CTVT) is a contagious cancer that is
naturally transmitted between dogs by the allogeneic transfer of living cancer cells during …

[HTML][HTML] The singular history of a canine transmissible tumor

EA Ostrander - Cell, 2006 - cell.com
In this issue of Cell, Murgia et al.(2006) confirm that the infectious agent of canine
transmissible venereal tumor is the cancer cell itself and that the tumor is clonal in origin …

Population genetics of clonally transmissible cancers

M Ní Leathlobhair, RE Lenski - Nature Ecology & Evolution, 2022 - nature.com
Populations of cancer cells are subject to the same core evolutionary processes as
asexually reproducing, unicellular organisms. Transmissible cancers are particularly striking …

Identification of canine transmissible venereal tumor cells using in situ polymerase chain reaction and the stable sequence of the long interspersed nuclear element

KW Liao, ZY Lin, HN Pao, SY Kam… - Journal of …, 2003 - journals.sagepub.com
Canine transmissible venereal tumor (CTVT) is a unique tumor that can be transplanted
across the major histocompatibility complex (MHC) barrier by viable tumor cells. In dogs …

Canine transmissible venereal tumour: cytogenetic origin, immunophenotype, and immunobiology. A review

S Mukaratirwa, E Gruys - Veterinary Quarterly, 2003 - Taylor & Francis
Canine transmissible venereal tumour (CTVT) is the only known naturally occurring tumour
that can be transplanted as an allograft across major histocompatibility (MHC) barriers within …