The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes

F Rubino, A Forgione, DE Cummings, M Vix… - Annals of …, 2006 - journals.lww.com
Methods: Goto-Kakizaki (GK) type 2 diabetic rats underwent duodenal-jejunal bypass (DJB),
a stomach-preserving RYGB that excludes the proximal intestine, or a gastrojejunostomy …

Effect of duodenal–jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease

F Rubino, J Marescaux - Annals of surgery, 2004 - journals.lww.com
Background: The Roux-en-Y gastric bypass and the biliopancreatic diversion effectively
induce weight loss and long-term control of type 2 diabetes in morbidly obese individuals. It …

Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1

M Speck, YM Cho, A Asadi… - American Journal of …, 2011 - journals.physiology.org
Dramatic improvement of type 2 diabetes is commonly observed after bariatric surgery.
However, the mechanisms behind the alterations in glucose homeostasis are still elusive …

The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats

D Pacheco, DA de Luis, A Romero, MG Sagrado… - The American journal of …, 2007 - Elsevier
BACKGROUND: The antidiabetic effect of bariatric surgery has been interpreted as a
conceivable result of surgically induced weight loss and decreased caloric intake. However …

Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery

DE Cummings, J Overduin, KE Foster-Schubert… - Surgery for Obesity and …, 2007 - soard.org
Among the panoply of obesity-related co-morbidities that are ameliorated by bariatric
surgery, perhaps the most impressive and scientifically interesting is the rapid, dependable …

Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing …

TT Wang, HD Gao, GY Zhang, CZ Liu, JB Feng… - Annals of …, 2008 - journals.lww.com
Objective: Modified duodenal jejunal bypass (MDJB) and ileal transposition (IT) were
compared as surgeries for glucose control. Initial conclusions might be formed with respect …

Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport

AT Stearns, A Balakrishnan… - American Journal of …, 2009 - journals.physiology.org
Roux-en-Y gastric bypass (RYGB) has become the gold-standard bariatric procedure, partly
because of the rapid resolution of accompanying diabetes. There is increasing evidence this …

Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism

TL Kindel, SM Yoder, RJ Seeley, DA D'Alessio… - Journal of …, 2009 - Elsevier
Background Gastric bypass results in the rapid resolution of type 2 diabetes. No causal
evidence exists to link specific gut hormone changes with improvements in glucose …

Is type 2 diabetes an operable intestinal disease? A provocative yet reasonable hypothesis

F Rubino - Diabetes care, 2008 - Am Diabetes Assoc
Type 2 diabetes, which accounts for 90–95% of all cases of diabetes, is a growing epidemic
that places a severe burden on health care systems, especially in developing countries …

Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model

A Patriti, E Facchiano, C Annetti, MC Aisa, F Galli… - Obesity surgery, 2005 - Springer
Background: Surgical operations which shorten the intestinal tract between the stomach and
the terminal ileum result in an early improvement in type 2 diabetes, and one possible …