Protection from direct cerebral cryptococcus infection by interferon-γ-dependent activation of microglial cells
Q Zhou, RA Gault, TR Kozel… - The Journal of …, 2007 - journals.aai.org
The brain represents a significant barrier for protective immune responses in both infectious
disease and cancer. We have recently demonstrated that immunotherapy with anti-CD40 …
disease and cancer. We have recently demonstrated that immunotherapy with anti-CD40 …
Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis
Cryptococcus neoformans is a ubiquitous fungus that can cause life-threatening infections
during immunosuppressive states such as AIDS and after bone marrow transplantation. In …
during immunosuppressive states such as AIDS and after bone marrow transplantation. In …
Resistance to Cryptococcus neoformans infection in the absence of CD4+ T cells
K Aguirre, J Crowe, A Haas, J Smith - Medical mycology, 2004 - Taylor & Francis
Previous studies of Cryptococcus neoformans infection have revealed a role for CD4+ T
cells and CD8+ T cells in anticryptococcal resistance in the lungs, but such a role has been …
cells and CD8+ T cells in anticryptococcal resistance in the lungs, but such a role has been …
Cryptococcus neoformans Induces Macrophage Inflammatory Protein 1α (MIP-1α) and MIP-1β in Human Microglia: Role of Specific Antibody and Soluble Capsular …
D Goldman, X Song, R Kitai, A Casadevall… - Infection and …, 2001 - Am Soc Microbiol
We characterized the expression of the β-chemokines macrophage inflammatory protein 1α
(MIP-1α), MIP-1β, and RANTES by primary human microglia after exposure to Cryptococcus …
(MIP-1α), MIP-1β, and RANTES by primary human microglia after exposure to Cryptococcus …
Role of Capsule and Interleukin-6 in Long-Term Immune Control of Cryptococcus neoformans Infection by Specifically Activated Human Peripheral Blood …
AA Siddiqui, RJ Shattock, TS Harrison - Infection and immunity, 2006 - Am Soc Microbiol
Cryptococcus neoformans is a frequent cause of meningoencephalitis in
immunosuppressed individuals. To better understand the mechanisms of a protective …
immunosuppressed individuals. To better understand the mechanisms of a protective …
Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization
E Blasi, R Barluzzi, R Mazzolla, P Mosci… - Infection and …, 1992 - Am Soc Microbiol
A murine model of intracerebral (ic) infection with Cryptococcus neoformans in which naive
mice receiving an ic fungal inoculation developed a severe disease has been established …
mice receiving an ic fungal inoculation developed a severe disease has been established …
Role of CD4+ T cells in a protective immune response against Cryptococcus neoformans in the central nervous system
WC Uicker, JP McCracken, KL Buchanan - Sabouraudia, 2006 - academic.oup.com
Cryptococcosis is a life-threatening disease caused by the encapsulated yeast,
Cryptococcus neoformans. Although infection with C. neoformans is initiated in the lungs …
Cryptococcus neoformans. Although infection with C. neoformans is initiated in the lungs …
Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice
KL Buchanan, HA Doyle - Infection and immunity, 2000 - Am Soc Microbiol
The importance of cell-mediated immunity (CMI) and CD4+ T lymphocytes in host resistance
against Cryptococcus neoformans is well documented and is exemplified by the high …
against Cryptococcus neoformans is well documented and is exemplified by the high …
MHC class II‐positive perivascular microglial cells mediate resistance to Cryptococcus neoformans brain infection
K Aguirre, S Miller - Glia, 2002 - Wiley Online Library
Acquired resistance to the CNS pathogen Cryptococcus neoformans is mediated by CD4+ T
lymphocytes primed by exposure to antigen in the context of major histocompatibility class II …
lymphocytes primed by exposure to antigen in the context of major histocompatibility class II …
IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis
W Stenzel, U Müller, G Köhler, FL Heppner… - The American journal of …, 2009 - Elsevier
Both interleukin (IL)-4-and IL-13-dependent Th2-mediated immune mechanisms exacerbate
murine Cryptococcus neoformans-induced bronchopulmonary disease. To study the roles of …
murine Cryptococcus neoformans-induced bronchopulmonary disease. To study the roles of …