[HTML][HTML] Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection

JA Nick, RM Dedrick, AL Gray, EK Vladar, BE Smith… - Cell, 2022 - cell.com
Two mycobacteriophages were administered intravenously to a male with treatment-
refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung …

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

RM Dedrick, BE Smith, M Cristinziano… - Clinical infectious …, 2023 - academic.oup.com
Abstract Background Nontuberculous Mycobacterium infections, particularly Mycobacterium
abscessus, are increasingly common among patients with cystic fibrosis and chronic …

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

RM Dedrick, CA Guerrero-Bustamante, RA Garlena… - Nature medicine, 2019 - nature.com
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus
infection was treated with a three-phage cocktail following bilateral lung transplantation …

Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

RM Dedrick, KG Freeman, JA Nguyen… - Nature medicine, 2021 - nature.com
Abstractpost An 81-year-old immunocompetent patient with bronchiectasis and refractory
Mycobacterium abscessus lung disease was treated for 6 months with a three-phage …

Mycobacterium abscessus strain morphotype determines phage susceptibility, the repertoire of therapeutically useful phages, and phage resistance

RM Dedrick, BE Smith, RA Garlena, DA Russell… - MBio, 2021 - Am Soc Microbiol
Mycobacterium abscessus is an opportunistic pathogen whose treatment is confounded by
widespread multidrug resistance. The therapeutic use of bacteriophages against …

[HTML][HTML] Mycobacterium abscessus: It's Complex

HFM Abdelaal, ED Chan, L Young, SL Baldwin… - Microorganisms, 2022 - mdpi.com
Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing
abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no …

[HTML][HTML] Pulmonary Bacteriophage Therapy on Pseudomonas aeruginosa Cystic Fibrosis Strains: First Steps Towards Treatment and …

E Morello, E Saussereau, D Maura, M Huerre… - PloS one, 2011 - journals.plos.org
Multidrug-resistant bacteria are the cause of an increasing number of deadly pulmonary
infections. Because there is currently a paucity of novel antibiotics, phage therapy—the use …

Bacteriophages ϕMR299-2 and ϕNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells

D Alemayehu, PG Casey, O McAuliffe, CM Guinane… - MBio, 2012 - Am Soc Microbiol
Pseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic
fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are …

Fatal Pulmonary Infection Due to Multidrug-Resistant Mycobacterium abscessus in a Patient with Cystic Fibrosis

M Sanguinetti, F Ardito, E Fiscarelli… - Journal of clinical …, 2001 - Am Soc Microbiol
We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a
young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year …

Animal model of Mycobacterium abscessus lung infection

D Ordway, M Henao-Tamayo, E Smith… - Journal of Leucocyte …, 2008 - academic.oup.com
Chronic lung disease as a result of Mycobacterium abscessus is an emerging infection in
the United States. We characterized the lung immune responses in mice and guinea pigs …