The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the
existence of disturbed sleep–wake and core body temperature rhythms, all suggest that …

In normal subjects, the secretion of melatonin, the pineal hormone that regulates the rhythm
of many functions, exhibits a circadian pattern synchronized with the day–night cycle. An …

Melatonin, at the same doses used to treat circadian-rhythm related sleep disturbances, had
no effect on the depressive symptoms in seasonal affective disorder (SAD) patients, whether …

Melatonin signals time of day and time of year in mammals by virtue of its pattern of
secretion, which defines 'biological night.'It is supremely important for research on the …

We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder
(SAD) and 20 healthy volunteers. Patients and controls were individually matched for age …

Serum melatonin levels over a 24 hr period were studied in 30 acutely ill patients with major
depressive episode, 24 patients with a history of unipolar or bipolar major affective disorder …

OBJECTIVE: The authors' goal was to examine the hypnotic effects of slow-release
melatonin during the initial 4 weeks of treatment with fluoxetine in 19 patients with major …

Melatonin is a methoxyindole synthesized and secreted principally by the pineal gland at
night under normal environmental conditions. The endogenous rhythm of secretion is …

The circadian rhythm of plasma melatonin was investigated in normal men 18–30 years (N=
5), normal men 50–70 years (N= 5) and in six patients with endogenous depression. 2. The …

Abstract Purpose of Review We present a review of research on the role of melatonin in the
management of sleep and circadian disorders, stressing current overall view of the …