Due to the high mortality of lung cancer, there is a critical need to develop diagnostic
procedures enabling early detection of the disease while at a curable stage. Targeted …

A divalent knottin containing two separate integrin binding epitopes (RGD) in the adjacent
loops, 3-4A, was recently developed and reported in our previous publication. In the current …

Purpose: Cystine knot (knottin) peptides, engineered to bind with high affinity to integrin
receptors, have shown promise as molecular imaging agents in living subjects. The aim of …

Knottins are small constrained polypeptides that share a common disulfide-bonded
framework and a triple-stranded β-sheet fold. Previously, directed evolution of the Ecballium …

There is a critical need for molecular imaging agents to detect cell surface integrin receptors
that are present in human cancers. Previously, we used directed evolution to engineer …

Purpose Molecular imaging using positron emission tomography (PET) radiotracers targeted
to tumor vasculature offers a noninvasive method for early detection of tumor angiogenesis …

Integrin αvβ6 has been considered as a promising biomarker for lung cancer, and its
expression is often related to poor prognosis. An αvβ6-binding cystine knot peptide R01-MG …

Previously, we used directed evolution to engineer mutants of the Ecballium elaterium
trypsin inhibitor (EETI-II) knottin that bind to αvβ3 and αvβ5 integrin receptors with low …

A series of radiolabeled cyclic arginine-glycineaspartic acid (RGD) peptide ligands for cell
adhesion molecule integrin αβ 3-targeted tumor angiogenesis targeting are being …

Abstract 64 Cu-cyclam-RAFT-c (-RGDfK-) 4 is a novel multimeric positron emission
tomography (PET) probe for α V β 3 integrin imaging. Its uptake and α V β 3 expression in …